Liposcale

Use of multivariate chemometric algorithms on 1H NMR data to assess a soluble fiber (Plantago ovata husk) nutritional intervention

Abstract The study of nutritional interventions in humans is difficult to assess because the induced metabolic changes are lower than the natural biological variability between subjects. Due to its holistic approach, 1H NMR is one of the preferred technologies for this type of studies, even though it has a very low sensitivity. This work shows… Read More »Use of multivariate chemometric algorithms on 1H NMR data to assess a soluble fiber (Plantago ovata husk) nutritional intervention

Particle size measurement of lipoprotein fractions using diffusion-ordered NMR spectroscopy

Abstract The sizes of certain types of lipoprotein particles have been associated with an increased risk of cardiovascular disease. However, there is currently no gold standard technique for the determination of this parameter. Here, we propose an analytical procedure to measure lipoprotein particles sizes using diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY). The method was tested… Read More »Particle size measurement of lipoprotein fractions using diffusion-ordered NMR spectroscopy

Surface fitting of 2D diffusion-edited 1H NMR spectroscopy data for the characterisation of human plasma lipoproteins

Abstract Determining the concentration and size of lipoprotein complexes is very important due to their role in cardiovascular diseases and metabolic disorders. However, standard methods for lipoprotein fractionation are manual and time consuming and cannot be used as standard diagnostic tools. Because different subclasses of lipoproteins have different radii and, hence, different diffusion velocities, we… Read More »Surface fitting of 2D diffusion-edited 1H NMR spectroscopy data for the characterisation of human plasma lipoproteins

Metabolomics Reveals Reduction of Metabolic Oxidation in Women with Polycystic Ovary Syndrome after Pioglitazone-Flutamide-Metformin Polytherapy

Abstract Polycystic ovary syndrome (PCOS) is a variable disorder characterized by a broad spectrum of anomalies, including hyperandrogenemia, insulin resistance, dyslipidemia, body adiposity, low-grade inflammation and increased cardiovascular disease risks. Recently, a new polytherapy consisting of low-dose flutamide, metformin and pioglitazone in combination with an estro-progestagen resulted in the regulation of endocrine clinical markers in… Read More »Metabolomics Reveals Reduction of Metabolic Oxidation in Women with Polycystic Ovary Syndrome after Pioglitazone-Flutamide-Metformin Polytherapy

Biosfer was awarded with the INNOWWIDE: a high competitive European call

Recently our CEO, Núria Amigó, was invited to participate in the first INNOWWIDE Focus Group, a virtual meeting organized by Steinbeis 2i innovative + international, as an INNOWWIDE funding recipient representative, to evaluate the call impact and to get insight the entire process, enabling to see those activities which we were good at and those… Read More »Biosfer was awarded with the INNOWWIDE: a high competitive European call

Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles

Our lipoprotein profile, Liposcale (CE), in Cardiovascular Diabetology: “Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles” The research groups of Sant Pau and Hospital Clinic lead by Dr. Didac Mauricio, Dr. Emilio Ortega and Dr. Antonio Amor have published a relevant study including more than 500 type 1 Diabetic… Read More »Advanced lipoprotein profile disturbances in type 1 diabetes mellitus: a focus on LDL particles