Liposcale

Metabolomics arrives at “The liver Meeting” comes from Biosfer Teslab

From 12 to 15 November took place the “The liver Meeting” organised by the American Association for the Study of Liver Diseases (AASLD). The mission of the association is to advance and disseminate the science and practice of hepatology, and to promote liver health. This year, Biosfer Teslab, together with OWL Metabolomics, University of Medicine… Read More »Metabolomics arrives at “The liver Meeting” comes from Biosfer Teslab

Metabolòmica al the Liver meeting

Barça Innovation Hub: Metabolomics at the forefront of elite sport

The Barça Innovation Hub (BIHUB) was created four years ago by the FC Barcelona to develop technological advances applied to sport and improve performance at the highest level. This large Barça Laboratory aims to exploit the synergy between sport and technology in order to reach the levels of demand required by the club. To work at… Read More »Barça Innovation Hub: Metabolomics at the forefront of elite sport

Liposcale for early and reliable diagnosis and prognosis of breast cancer patients

One of the key features of malignant tumour cells is that their energy metabolism is altered. However, in recent years, alterations in lipid metabolism have been described in some types of cancer. A study led by the team of Dr. Josep Gumà and Dr. Sandra Guaita from the Pere Virgili Health Research Institute (IISPV) and… Read More »Liposcale for early and reliable diagnosis and prognosis of breast cancer patients

Liposcale Breast cancer

Liposcale in Circulation

Frequent consumption of nuts, an important component of plant-based diets, is associated with a 15% reduction in total cardiovascular disease (CVD) and a 23% reduction in CVD mortality. Although small studies have shown that supplementing the diet with nuts has a considerable effect on reducing dietary cholesterol in the short term, there is little information… Read More »Liposcale in Circulation

Liposcale in Circulation

Improvement in the prediction of atheromatous cardiovascular disease using the Liposcale test

Patients with chronic kidney disease (CKD) have a high burden of atheromatous cardiovascular disease (ASCVD) that is not fully explained by traditional lipid parameters. A study published in the clinical Kidney journal, conducted in patients with chronic kidney disease, reveals that information on lipoprotein composition and subclass particle number using the Liposcale test could improve… Read More »Improvement in the prediction of atheromatous cardiovascular disease using the Liposcale test

malaltia cardiovascular ateromatosa

Early molecular signature of Parkinson and dementia years before the diseases appear

NMR metabolomics could identify altered lipoprotein and protein glycosylation profiles in REM sleep behavior disorder (iRBD), the prodromal stage of Lewy-type synucleinopathies (LTS) -including Parkinson and dementia. NMR showed predictive power distinguishing future clinical outcome, being a useful tool for identifying short-term high-risk patients for conversion to parkinsonism or dementia. Here you can see the… Read More »Early molecular signature of Parkinson and dementia years before the diseases appear

Use of multivariate chemometric algorithms on 1H NMR data to assess a soluble fiber (Plantago ovata husk) nutritional intervention

Abstract The study of nutritional interventions in humans is difficult to assess because the induced metabolic changes are lower than the natural biological variability between subjects. Due to its holistic approach, 1H NMR is one of the preferred technologies for this type of studies, even though it has a very low sensitivity. This work shows… Read More »Use of multivariate chemometric algorithms on 1H NMR data to assess a soluble fiber (Plantago ovata husk) nutritional intervention

Particle size measurement of lipoprotein fractions using diffusion-ordered NMR spectroscopy

Abstract The sizes of certain types of lipoprotein particles have been associated with an increased risk of cardiovascular disease. However, there is currently no gold standard technique for the determination of this parameter. Here, we propose an analytical procedure to measure lipoprotein particles sizes using diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY). The method was tested… Read More »Particle size measurement of lipoprotein fractions using diffusion-ordered NMR spectroscopy

Surface fitting of 2D diffusion-edited 1H NMR spectroscopy data for the characterisation of human plasma lipoproteins

Abstract Determining the concentration and size of lipoprotein complexes is very important due to their role in cardiovascular diseases and metabolic disorders. However, standard methods for lipoprotein fractionation are manual and time consuming and cannot be used as standard diagnostic tools. Because different subclasses of lipoproteins have different radii and, hence, different diffusion velocities, we… Read More »Surface fitting of 2D diffusion-edited 1H NMR spectroscopy data for the characterisation of human plasma lipoproteins

Metabolomics Reveals Reduction of Metabolic Oxidation in Women with Polycystic Ovary Syndrome after Pioglitazone-Flutamide-Metformin Polytherapy

Abstract Polycystic ovary syndrome (PCOS) is a variable disorder characterized by a broad spectrum of anomalies, including hyperandrogenemia, insulin resistance, dyslipidemia, body adiposity, low-grade inflammation and increased cardiovascular disease risks. Recently, a new polytherapy consisting of low-dose flutamide, metformin and pioglitazone in combination with an estro-progestagen resulted in the regulation of endocrine clinical markers in… Read More »Metabolomics Reveals Reduction of Metabolic Oxidation in Women with Polycystic Ovary Syndrome after Pioglitazone-Flutamide-Metformin Polytherapy