Applications

Nuclear Magnetic Resonance (NMR) metabolomics is an exceedingly versatile analytical technique, offering a broad spectrum of applications by virtue of its capacity to non-invasively and comprehensively profile small molecules in biological samples. Beyond qualitative and quantitative metabolite analysis, it finds utility across a diverse range of biological matrices, encompassing biofluids, tissues, and cell extracts. Its versatility further encompasses the identification and quantification of established metabolites as well as the exploration of novel biomarkers or compounds. Its adaptability enables the handling of an extensive array of sample types, from intricate metabolic profiling in clinical and pharmaceutical research to the analysis of complex mixtures in environmental samples. Finally, its non-destructive character and minimal sample preparation prerequisites render this technology an invaluable tool for investigating a wide spectrum of biological systems, thereby facilitating advancements in domains such as disease biomarker discovery, drug metabolism studies, and personalized medicine

Who can benefit from our services?

Nuclear Magnetic Resonance (NMR) metabolomics exhibits a versatile spectrum of applications, affording a multitude of sectors such as universities, research centers, health professionals, pharmaceutical companies, food companies or clinical analysis laboratories the opportunity to leverage its diverse capabilities to their advantage.

Health screening

Prediction / Prevention

Epidemiological studies

Genetic diseases

Biomarker discovery

Nutritional intervention

Diagnosis

Pharmacological studies

Cardiometabolic disease

Cardiovascular disease (CVD) presents a significant worldwide health challenge, impacting millions of individuals. Encompassing heart-related conditions like heart attacks, strokes, and heart failure, CVD remains the leading global cause of death, placing strain on healthcare systems and economies. Its prevalence is influenced by factors such as unhealthy habits, tobacco consumption, inadequate diets, lack of physical activity, and genetic factors. To address CVD’s growing impact, there’s a need for innovative technologies aimed at early detection and treatment monitoring, with the goal of mitigating risk factors and fostering global cardiovascular well-being.

Metabolomics has emerged as a powerful tool in unraveling the complex landscape of CVD. By analyzing a broad spectrum of metabolites within biological samples, metabolomics offers a comprehensive view of the metabolic processes underlying CVD, paving the way for early detection, risk assessment, and tailored interventions.

In the context of cardiovascular disease, metabolomics can provide insights into both the underlying mechanisms and potential biomarkers associated with different stages of the disease. Metabolite profiles can reveal metabolic disruptions, highlighting shifts in pathways related to energy metabolism, lipid regulation, inflammation, and oxidative stress. These insights can aid in deciphering the intricate interplay of factors contributing to CVD development and progression.

Nutritional Interventions

Metabolomics is a powerful tool to revolutionize the way we monitor and understand the effects of nutritional interventions. By analyzing a comprehensive range of metabolites within biological samples, metabolomics provides a detailed snapshot of an individual’s metabolic profile. This includes the dynamic changes occurring as a result of dietary modifications.

When it comes to nutritional interventions, metabolomics can provide invaluable insights. For instance, if a person is undergoing a specific dietary regimen, metabolomics analysis can track alterations in metabolite levels that directly relate to nutrient intake and utilization.

The integration of metabolomics with advanced data analysis techniques, such as machine learning and artificial intelligence, enhances the precision and predictive capacity of monitoring nutritional interventions. Patterns and trends within vast metabolomics datasets can be identified, aiding in the customization of dietary plans based on an individual’s unique metabolic responses.

Cancer

Cancer, a complex and heterogeneous group of diseases, represents a significant global health challenge. Despite advancements in research and medical interventions, cancer remains a leading cause of morbidity and mortality worldwide. The crucial role of early detection and prognostic techniques is essential in our fight against the disease, as persistent research advances both our comprehension and the refinement of treatment strategies.

Metabolomics has emerged as a potent tool in the study of cancer. Focused on comprehensively analyzing a great array of metabolites within biological systems, metabolomics offers a unique perspective on the intricate metabolic alterations that accompany various types of cancer. Through metabolomics, researchers can identify specific metabolic signatures associated with different cancer types, stages, and even individual patients. These signatures serve as potential biomarkers that offer insights into early detection, prognosis, and treatment response.

Metabolomics in combination with the use of advanced data analytics and machine learning empowers the identification of intricate metabolic patterns that might otherwise go unnoticed.

Chronic kidney disease

This condition entails a progressive decline in kidney function. The kidneys play a pivotal role in filtering out waste products and surplus fluids from the bloodstream, which are then excreted through urine. Chronic kidney disease has garnered recognition as a prominent worldwide public health concern, closely intertwined with diabetes, hypertension, and the aging demographics of the population, as acknowledged by the World Health Organization. Metabolomics is proving to be a transformative tool in unraveling the complexities of chronic kidney disease (CKD). Metabolomics, through its comprehensive analysis of metabolites within biological samples, provides a unique window into the intricate metabolic perturbations that underlie the development and progression of CKD.

This in-depth understanding allows researchers to uncover specific metabolite patterns that may serve as early diagnostic markers, prognostic indicators, and even offer insights into potential therapeutic interventions. Moreover, metabolomics sheds light on the intricate metabolic interplay between the kidneys and other organs, providing a holistic perspective on the systemic impact of CKD.

Metabolomics in combination with advanced computational techniques further enable the identification of subtle metabolic changes that might otherwise go unnoticed.

Metabolic disease in fetal growth/infancy

Early life stages lay the foundation for long-term health, and identifying potential risks at the outset can significantly impact future well-being. Metabolic diseases, such as obesity and diabetes, can have their origins during fetal development and infancy. This critical period presents a unique window of opportunity for intervention and prevention. Innovative tools, like advanced metabolomics, offer a comprehensive analysis of metabolic pathways, enabling the early detection of deviations that might indicate an increased susceptibility to metabolic disorders. By identifying these risks in a timely manner, healthcare providers can tailor interventions and guide parents towards informed decisions that foster a healthier trajectory for their child’s metabolic health.

Autoimmune disease

The realm of autoimmune diseases demands the incorporation of innovative tools to address the complexities of diagnosis, treatment, and management. These conditions, characterized by the body’s immune system attacking its own tissues, present intricate challenges that often require novel approaches. Traditional diagnostic methods may fall short in capturing the nuances of autoimmune disorders, which can manifest with diverse and overlapping symptoms.

Metabolomics offers a unique lens into the intricate metabolic disruptions associated with autoimmune diseases. By uncovering specific metabolite patterns and metabolic pathways that are altered in these conditions, metabolomics holds the potential to revolutionize diagnostics, provide insights into disease mechanisms, and guide personalized treatment approaches. The invaluable information derived from metabolomics has the power to enhance early detection, monitor disease progression, and identify novel therapeutic targets. As the importance of personalized medicine grows, metabolomics emerges as a transformative tool in unraveling the complexities of autoimmune diseases, ultimately paving the way for more effective interventions and improved patient outcomes.