The Atherogenic Triad: The Risk Phenotype in the Metabolic Patient
Introduction Atherogenic dyslipidemia (AD) is a complex metabolic condition that is highly prevalent in individuals with obesity, metabolic syndrome, and type 2 diabetes. It is characterized by a specific imbalance: elevated triglyceride (TG) levels, low concentrations of HDL cholesterol (HDL-C), and a qualitative increase in LDL particles, which become smaller and denser (sdLDL). The most […]
The Lipid Silhouette: A Visual Snapshot of Cardiovascular Risk in the Liposcale Report
Visualizing cardiovascular risk in a single image As science advances, the amount of data generated to assess cardiovascular risk (CVR) continues to grow, including the composition, size, and number of lipoprotein subclasses. To make this wealth of information useful for rapid clinical decision-making, it is essential to have tools for visualization and interpretative summarization. The […]
The Number of LDL Particles: The Hidden Metric That Explains True Atherosclerotic Risk in Dyslipidemia
LDL-C as a Traditional Therapeutic Target Historically, LDL-C has been maintained as the primary therapeutic target in the prevention of atherosclerotic cardiovascular disease (ASCVD), with the goal of reducing its plasma concentration as much as possible. However, the prevalence of residual risk—even in patients with LDL-C levels within the optimal range—has compelled the scientific community […]
Low-Grade Inflammation and Glycoproteins: New Evidence After Metabolic Surgery
Low-Grade Inflammation: The Invisible Thread Connecting Obesity and Cardiometabolic Risk Obesity is not merely an excess of weight; it is a complex disease associated with a chronic, low-grade inflammatory state—silent yet persistent—that contributes to the development of type 2 diabetes, hypertension, fatty liver, and cardiovascular disease. This state arises from the expansion of adipose tissue, […]
Obesity Affects Men and Women Differently: New Insights into the Lipoprotein Profile
A recent study published in Lipids in Health and Disease (Santisteban et al., 2025) offers a new perspective on how sex and body mass index influence lipoprotein metabolism, even in individuals considered metabolically healthy. The research, authored by Victoria Santisteban(1,2), Anallely López-Yerena (1,3,4), Natàlia Muñoz-Garcia (1), Gemma Vilahur (1,5), Lina Badimon (1,5,6), and Teresa Padró […]
Gut microbiota and metabolism associated with CAR-T therapy response in multiple myeloma
Gut microbiota and metabolism associated with CAR-T therapy response in multiple myeloma A recent work published by Mireia Uribe-Herranz¹⁺², Aina Oliver-Caldés¹⁺³, Neus Martínez-Micaelo⁴, Marta Español-Rego², Maria Val-Casals¹⁺⁵, Roberto Martínez-Soler¹, Elisa Rubio-Garcia⁶⁺⁷⁺⁸⁺⁹, Valeria Brunello¹, Erik Z. Mihelic¹, Nela Klein-González¹⁺²⁺⁵, Daniel Benítez-Ribas², Núria Amigó⁴⁺¹⁰⁺¹¹, Andrea Vergara⁶⁺⁷⁺⁹⁺¹², Valentin Ortiz-Maldonado³, Luis Gerardo Rodríguez-Lobato¹⁺³, Julio Delgado³, Iñaki Ortiz […]
Triglycerides: More Than a Marker — A Driver of Cardiovascular Risk
Triglycerides: More Than a Marker — A Driver of Cardiovascular Risk Introduction: The Residual Risk Beyond LDL Cholesterol For decades, LDL cholesterol has been considered the main enemy in cardiovascular prevention. However, numerous studies — including the FOURIER-OLE trial — have shown that even patients with extremely low LDL-C levels continue to experience […]
ASCAHIFA and Biosfer Teslab on Familial Hypercholesterolemia Day
ASCAHIFA and Biosfer Teslab join forces to advance the diagnosis of familial hypercholesterolemia with Liposcale® On September 24, we celebrate Familial Hypercholesterolemia (FH) Day, a hereditary genetic condition that causes very high levels of LDL cholesterol from birth and greatly increases the risk of developing premature cardiovascular disease. It is estimated that FH affects 1 […]
When LDL Cholesterol Doesn’t Tell the Whole Story: A Clinical Case of Hidden Cardiovascular Risk
The Challenge of Residual Risk in Cardiovascular Health Cardiovascular diseases remain the leading cause of death worldwide.Despite preventive efforts—such as controlling LDL cholesterol, blood pressure, and glucose levels—many individuals still suffer heart attacks or strokes even with apparently “normal” values. This phenomenon is known as residual cardiovascular risk, and it accounts for up […]
NMR Metabolomics in Animal Models: A Key Tool for Translational Research
In biomedical research, animal models represent a fundamental tool for understanding the pathophysiological mechanisms of human diseases and for exploring new therapeutic strategies. They allow for the controlled reproduction of complex clinical conditions, the study of disease progression—particularly in chronic or metabolic disorders—and the evaluation of interventions before their application in humans. In […]