Improvement in the prediction of atheromatous cardiovascular disease using the Liposcale test
Patients with chronic kidney disease (CKD) have a high burden of atheromatous cardiovascular disease (ASCVD) that is not fully explained by traditional lipid parameters. A study published in the clinical Kidney journal, conducted in patients with chronic kidney disease, reveals that information on lipoprotein composition and subclass particle number using the Liposcale test could improve […]
Particle size measurement of lipoprotein fractions using diffusion-ordered NMR spectroscopy
Abstract The sizes of certain types of lipoprotein particles have been associated with an increased risk of cardiovascular disease. However, there is currently no gold standard technique for the determination of this parameter. Here, we propose an analytical procedure to measure lipoprotein particles sizes using diffusion-ordered nuclear magnetic resonance spectroscopy (DOSY). The method was tested […]
Surface fitting of 2D diffusion-edited 1H NMR spectroscopy data for the characterisation of human plasma lipoproteins
Abstract Determining the concentration and size of lipoprotein complexes is very important due to their role in cardiovascular diseases and metabolic disorders. However, standard methods for lipoprotein fractionation are manual and time consuming and cannot be used as standard diagnostic tools. Because different subclasses of lipoproteins have different radii and, hence, different diffusion velocities, we […]
