Assessment of physical status and analysis of lipidomic and metabolomic alterations in patients with Post-COVID-19 condition
Abstract The development and persistence of symptoms following SARS-CoV-2 infection, known as Post-COVID-19 Condition (PCC) or “long COVID,” represents a global health challenge. In this prospective cross-sectional study, we conducted a detailed assessment of the physical condition of 46 patients using handgrip dynamometry, ergoespirometry, and the 6-minute walk test (6MWT). The results revealed a loss […]
Advanced lipoprotein, glycoprotein and lipidomic profiles in hyperalphalipoproteinemia with and without atherosclerotic cardiovascular disease: a case–control studyAdvanced lipoprotein, glycoprotein and lipidomic profiles in hyperalphalipoproteinemia with and without atherosclerotic cardiovascular disease: a case–control study
Abstract Despite the well-established protective role of HDL-cholesterol against atherosclerotic cardiovascular disease (ASCVD), several studies have observed a higher incidence of ASCVD in individuals with elevated HDL-cholesterol concentrations. This condition, known as hyperalphalipoproteinemia, appears to modify HDL composition, potentially resulting in a loss of its anti-atherogenic properties and, in some cases, a pro-atherogenic effect. This […]
Disease-specific crosstalk of Alistipes with lipoprotein profiles in overweight individuals at high cardiometabolic risk
Abstract Metabolic syndrome (MS) and systemic lupus erythematosus (SLE) represent two pathophysiologically distinct chronic conditions associated with elevated cardiovascular risk. Emerging evidence links gut microbiota to host lipid metabolism and lipoprotein function. This investigation aimed to analyze disease-specific relations between gut microbiota and an advanced lipoprotein profiling in an overweight population affected by MS and […]
The ALDH4A1/anti-ALDH4A1 axis as a novel player of atherosclerosis in rheumatoid arthritis
Abstract Objectives Cardiovascular risk excess in rheumatoid arthritis (RA) cannot be explained by traditional risk factors alone. Recent experimental data have identified ALDH4A1 as a mitochondrial self-antigen implicated in atherosclerosis, yet its clinical significance in human autoimmunity remains unexplored. We aimed to characterize ALDH4A1 and anti-ALDH4A1 antibody levels in early RA, and evaluate their associations […]
Prevalence of elevated lipoprotein(a) levels and associated atherosclerotic cardiovascular diseases in subjects with metabolic disorders: A real-world study in a lipid unit
Abstract Lipoprotein(a) (Lp(a)) is a proatherogenic particle that is considered an important cardiovascular risk modifier due to its association with atherosclerotic cardiovascular disease (ASCVD) as well as calcific aortic valve stenosis (CAVS). Data on the clinical burden associated with elevated lipoprotein(a) levels in patients at high and very high cardiovascular risk remain limited. We evaluated […]
Multilayer metabolomic integration reveals bioenergetic disruption in Long COVID
Abstract Background: Long COVID represents a significant health challenge, with 10–20% of patients with COVID-19 experiencing persistent multiorgan symptoms. The heterogeneity of clinical manifestations, combined with an incomplete understanding of the underlying molecular mechanisms, limits the improvement of patient management. Circulating metabolomic profiling constitutes a promising tool to address these limitations. In this context, we […]
A Potential Ratio for Detecting Subclinical Atherosclerosis: Insight into Advanced NMR Lipid Profiles in Severe Obesity
Abstract Individuals with severe obesity (SO) are at a high risk of developing cardiovascular disease, but traditional lipid parameters are insufficient for accurately assessing the risk. This study aims to investigate the advanced characteristics of lipoproteins that may contribute to subclinical atherosclerosis in SO and the impact of bariatric surgery (BS). The study included 37 […]
A Robust Multivariate Approach Unveils a 1 H-NMR-Based Spectral Metabolomics Signature Predictive of Cardiovascular Disease in People with Type 2 Diabetes: A Prospective Di@bet.es Cohort Study
Abstract Individuals with severe obesity (SO) are at a high risk of developing cardiovascular disease, but traditional lipid parameters are insufficient for accurately assessing the risk. This study aims to investigate the advanced characteristics of lipoproteins that may contribute to subclinical atherosclerosis in SO and the impact of bariatric surgery (BS). The study included 37 […]
Plasma protein glycosylation: a biomarker for predicting metabolic dysfunction-associated steatotic liver disease in inflammatory bowel disease
Abstract People with type 2 diabetes mellitus (T2DM) are at high risk of cardiovascular disease (CVD), which is often not explained by traditional risk factors such as low-density lipoprotein (LDL) cholesterol. Proton nuclear magnetic resonance (1H NMR) metabolomics is a promising tool to help explain this residual risk. This study aimed to evaluate the incidence […]
Widespread lipoprotein alterations in a REDUCE-IT like population: The icosapent ethyl (IPE)-NMR avatar study
Abstract Background and aim: Triglycerides (TG) are independent cardiovascular risk markers, yet TG-lowering therapies have failed to reduce major adverse cardiovascular events. However, high-dose icosapent ethyl (IPE) significantly reduces cardiovascular events in high-risk patients with controlled low-density lipoprotein cholesterol (LDL-C) and TG > 1.7 mmol/L. Elevated TG levels contribute to widespread lipoprotein metabolism disruptions, which […]