Lipidomic and Metabolomic Changes in Community-acquired and COVID-19 Pneumonia
Abstract This prospective observational study compared the 1H NMR blood lipidomes and metabolomes of 71 community-acquired pneumonia (CAP) patients, 75 COVID-19 pneumonia patients, and 75 healthy controls (matched by age and sex) to identify potential biomarkers and pathways associated with respiratory infections. Both pneumonia groups had comparable severity indices, including mortality, invasive mechanical ventilation, and […]
Investigating the Link between Intermediate Metabolism, Sexual Dimorphism, and Cardiac Autonomic Dysfunction in Patients with Type 1 Diabetes
Abstract Sexual dimorphism influences cardiovascular outcomes in type 1 diabetes (T1D), with women facing a higher relative risk of macrovascular events compared to men, especially after menopause. This study hypothesizes that abnormalities in intermediate metabolism may be associated with cardiac autonomic neuropathy (CAN) in T1D. We aim to assess low molecular weight metabolites (LMWM) as […]
Identification of a molecular signature associated with covid-19 severity using a comprehensive 1H-NMR serum metabolomics profiling strategy
Abstract Background and Aims:Atherogenic dyslipidemia together with specific pro-inflammatory profiles have been identified as markers of severe adverse outcomes in COVID-19 disease. This study aims to evaluate nuclear magnetic resonance (NMR)-based metabolomics combined with machine learning algorithms as a strategy to identify a molecular signature associated with poor CoVID-19 prognosis. Ver texto completo
Differential analysis of lipoprotein and glycoprotein profiles in bacterial infections and COVID-19 using proton NMR and machine learning
Abstract Methods We obtained sera from 124 patients with COVID-19, 50 patients with catheter-related bacterial infections, and 50 healthy volunteers. Results were interpreted using machine learning. Results COVID-19 patients had bigger and more abundant VLDL particles than the control group and higher VLDL-cholesterol and VLDL-triglyceride concentrations. Patients with bacterial infections showed similar trends, but differences […]
Higher adherence to the Mediterranean diet is associated with improved glycemic control and reduced atherogenic patterns: A population-based study
Abstract Background and Aims:The traditional Mediterranean diet (MedDiet) has been linked to a reduced incidence of type 2 diabetes, while a potential effect on advanced lipoprotein profiles is debated. We hypothesized that greater MedDiet adherence positively impacts both glycemic and lipoprotein profiles. Ver texto completo
The athero-contour: A novel tool for global and rapid assessment of atherogenic parameters. A use case in saroglitazar treatment of MAFLD patients
Abstract Background: Comprehensive assessment of pharmacotherapy effects on atherogenic parameters (AP) that influence the risk of cardiovascular disease (CVD) is challenging due to interactions among a large number of parameters that modulate CVD risk. Methods: We developed an illustrative tool, athero-contour (AC), which incorporates weighted key lipid, lipo- and glycoprotein parameters, to readily illustrate their […]
Remodeling of skeletal muscle myosin metabolic states in hibernating mammals
Abstract Hibernation is a period of metabolic suppression utilized by many small and large mammal species to survive during winter periods. As the underlying cellular and molecular mechanisms remain incompletely understood, our study aimed to determine whether skeletal muscle myosin and its metabolic efficiency undergo alterations during hibernation to optimize energy utilization. We isolated muscle […]
Increasing the complexity of lipoprotein characterization for cardiovascular risk in type 2 diabetes
Abstract The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between […]
Cardiovascular risk assessment in inflammatory bowel disease with metabolic dysfunction-associated steatotic liver disease
Abstract Background: Inflammatory bowel disease (IBD) has been reported to increase the risk of early atherosclerosis even in young patients. Moreover, metabolic dysfunction-associated steatotic liver disease (MASLD), which has been linked to IBD, is a well-recognized but underdiagnosis entity related to cardiovascular risk. We analyze the impact of MASLD in IBD patients’ cardiovascular risk through […]
Association between exposure to air pollution and blood lipids in the general population of Spain
Abstract Background: We aimed to assess the associations of exposure to air pollutants and standard and advanced lipoprotein measures, in a nationwide sample representative of the adult population of Spain.Methods: We included 4647 adults (>18 years), participants in the national, cross-sectional, population-based di@bet.es study, conducted in 2008–2010. Standard lipid measurements were analysed on an Architect C8000 Analyzer (Abbott […]
