Advanced Lipoproteins and Lipidomic Profile in Bariatric Surgery

Abstract Background: Obesity is related to cardiovascular risk factors (CVRF) such as dyslipidemia, diabetes, and hypertension, which increase mortality. Basic lipid determinations could underestimate the true atherogenic risk of patients and the impact of bariatric surgery. The objective of the study is to demonstrate the change in the advanced molecular profile of lipoproteins determined by nuclear […]

Asociación entre contaminación del aire y lípidos en sangre en España

Resumen Antecedentes y objetivos: Nuestro objetivo fue evaluar las asociaciones entre la exposición a contaminantes atmosféricos y medidas estándar y avanzadas de lipoproteínas, en una muestra a nivel nacional representativa de la población adulta de España. Métodos: Incluimos a 4647 adultos (>18 años), participantes en el estudio nacional, transversal y poblacional, realizado entre 2008 […]

Serum branch-chained amino acids are increased in type 2 diabetes

Abstract Background and aim: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 patients with metabolic diseases to assess their relationships with type-2 diabetes (T2D) […]

Increase in Inflammation-Linked Glycoproteins and a Proatherogenic Lipoprotein Profile in Psychosis

Abstract Minimally invasive prognostic markers of inflammation and dyslipidemia in individuals with a risk of psychosis, also called «at-risk mental state» (ARMS), or in the first episode of psychosis (FEP) are of utmost clinical importance to prevent cardiovascular disorders. We analyzed the plasma concentration of inflammation-linked glycoproteins (Glycs) and lipoprotein subclasses by proton nuclear magnetic […]

NMR-based metabolomic profiling identifies inflammation and muscle-related metabolites as predictors of incident type 2 diabetes mellitus beyond glucose: The study

Abstract Aims: The aim of this study was to combine nuclear magnetic resonance-based metabolomics and machine learning to find a glucose-independent molecular signature associated with future type 2 diabetes mellitus development in a subgroup of individuals from the study. Methods: The study group included 145 individuals developing type 2 diabetes mellitus during the 8-year follow-up, 145 […]

PCSK9 Inhibitors Have Apolipoprotein C-III-Related Anti-Inflammatory Activity, Assessed by 1H-NMR Glycoprotein Profile in Subjects at High or very High Cardiovascular Risk

Abstract Atherosclerosis is a chronic inflammatory disease caused by the accumulation of cholesterol in the intima. Proprotein convertase subtilisin/kexin type 9 inhibitors (iPCSK9) can reduce low-density lipoprotein (LDL) cholesterol levels by 60%, but there is still no evidence that they can lower markers of systemic inflammation such as high-sensitivity C-reactive protein (hsCRP). Acute-phase serum glycoproteins […]

Humoral responses against HDL are linked to lipoprotein traits, atherosclerosis, inflammation and pathogenic pathways during early arthritis stages

Abstract Objective: Chronic inflammation and immune dysregulation are crucial mechanisms for atherosclerosis in RA. Recent evidence suggests a link via humoral responses against high-density lipoproteins (HDL). This study aimed to characterize the specificity, clinical relevance and emergence of humoral responses against HDL along disease course, especially during the earliest phases of arthritis. Methods: IgG and IgM serum […]