Metabolomics Approach to Identify Biomarkers of Acute and Subacute Mastitis in Milk Samples: A Pilot Case-Control Study
Abstract Background and aims: Mastitis is one of the main complications during breastfeeding and contributes to the cessation of breastfeeding. However, the etiopathogenesis and diagnosis of mastitis are complex and not yet well defined. We aimed to identify metabolic and lipidic changes in human milk during acute and subacute mastitis in order to detect potential […]
Lipidomic and metabolomic changes in community-acquired and COVID-19 pneumonia
Abstract This prospective observational study compared the 1H NMR blood lipidomes and metabolomes of 71 patients with community-acquired pneumonia (CAP), 75 patients with COVID-19 pneumonia, and 75 healthy controls (matched by age and sex) to identify potential biomarkers and pathways associated with respiratory infections. Both pneumonia groups had comparable severity indices, including mortality, invasive mechanical […]
Lipidomic and Metabolomic Changes in Community-acquired and COVID-19 Pneumonia
Abstract This prospective observational study compared the 1H NMR blood lipidomes and metabolomes of 71 community-acquired pneumonia (CAP) patients, 75 COVID-19 pneumonia patients, and 75 healthy controls (matched by age and sex) to identify potential biomarkers and pathways associated with respiratory infections. Both pneumonia groups had comparable severity indices, including mortality, invasive mechanical ventilation, and […]
Investigating the Link between Intermediate Metabolism, Sexual Dimorphism, and Cardiac Autonomic Dysfunction in Patients with Type 1 Diabetes
Abstract Sexual dimorphism influences cardiovascular outcomes in type 1 diabetes (T1D), with women facing a higher relative risk of macrovascular events compared to men, especially after menopause. This study hypothesizes that abnormalities in intermediate metabolism may be associated with cardiac autonomic neuropathy (CAN) in T1D. We aim to assess low molecular weight metabolites (LMWM) as […]
Identification of a molecular signature associated with covid-19 severity using a comprehensive 1H-NMR serum metabolomics profiling strategy
Abstract Background and Aims:Atherogenic dyslipidemia together with specific pro-inflammatory profiles have been identified as markers of severe adverse outcomes in COVID-19 disease. This study aims to evaluate nuclear magnetic resonance (NMR)-based metabolomics combined with machine learning algorithms as a strategy to identify a molecular signature associated with poor CoVID-19 prognosis. Ver texto completo
Differential analysis of lipoprotein and glycoprotein profiles in bacterial infections and COVID-19 using proton NMR and machine learning
Abstract Methods We obtained sera from 124 patients with COVID-19, 50 patients with catheter-related bacterial infections, and 50 healthy volunteers. Results were interpreted using machine learning. Results COVID-19 patients had bigger and more abundant VLDL particles than the control group and higher VLDL-cholesterol and VLDL-triglyceride concentrations. Patients with bacterial infections showed similar trends, but differences […]
Higher adherence to the Mediterranean diet is associated with improved glycemic control and reduced atherogenic patterns: A population-based study
Abstract Background and Aims:The traditional Mediterranean diet (MedDiet) has been linked to a reduced incidence of type 2 diabetes, while a potential effect on advanced lipoprotein profiles is debated. We hypothesized that greater MedDiet adherence positively impacts both glycemic and lipoprotein profiles. Ver texto completo
Differential analysis of lipoprotein and glycoprotein profiles in bacterial infections and COVID-19 using proton nuclear magnetic resonance and machine learning
Abstract Background: We scrutinized variations in the proton nuclear magnetic resonance (1H NMR) lipoprotein and glycoprotein profiles among hospitalized individuals with infectious diseases. Methods: We obtained sera from 124 patients with COVID-19, 50 patients with catheter-related bacterial infections, and 50 healthy volunteers. Results were interpreted using machine learning. Results: COVID-19 patients had bigger and more […]
Increasing the complexity of lipoprotein characterization for cardiovascular risk in type 2 diabetes
Abstract The burden of cardiovascular disease is particularly high among individuals with diabetes, even when LDL cholesterol is normal or within the therapeutic target. Despite this, cholesterol accumulates in their arteries, in part, due to persistent atherogenic dyslipidaemia characterized by elevated triglycerides, remnant cholesterol, smaller LDL particles and reduced HDL cholesterol. The causal link between […]
Investigating the Link between Intermediate Metabolism, Sexual Dimorphism, and Cardiac Autonomic Dysfunction in Patients with Type 1 Diabetes
Abstract Sexual dimorphism influences cardiovascular outcomes in type 1 diabetes (T1D), with women facing a higher relative risk of macrovascular events compared to men, especially after menopause. This study hypothesizes that abnormalities in intermediate metabolism may be associated with cardiac autonomic neuropathy (CAN) in T1D. We aim to assess low molecular weight metabolites (LMWM) as […]