The Lipoprotein Profile Evaluated by 1H-NMR Improves the Performance of Genetic Testing in Familial Hypercholesterolemia
Abstract Background: The familial hypercholesterolemia (FH) diagnosis is based on clinical and genetic criteria. A relevant proportion of FH patients fulfilling the criteria for definite FH have negative genetic testing. Increasing the identification of true genetic-based FH is a clinical challenge. Deepening the analysis of lipoprotein alterations could help increase the yield of genetic testing. […]
Quantification of lipoproteins by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves the prediction of cardiac autonomic dysfunction in patients with type 1 diabetes
Abstract Aims: To assess if advanced characterization of serum glycoprotein and lipoprotein profile, measured by proton nuclear magnetic resonance spectroscopy (1H-NMRS) improves a predictive clinical model of cardioautonomic neuropathy (CAN) in subjects with type 1 diabetes (T1D). Methods: Cross-sectional study (ClinicalTrials.gov Identifier: NCT04950634). CAN was diagnosed using Ewing’s score. Advanced characterization of macromolecular complexes including glycoprotein […]
Traffic Density Exposure, Oxidative Stress Biomarkers and Plasma Metabolomics in a Population-Based Sample: The Hortega Study
Abstract Exposure to traffic-related air pollution (TRAP) generates oxidative stress, with downstream effects at the metabolic level. Human studies of traffic density and metabolomic markers, however, are rare. The main objective of this study was to evaluate the cross-sectional association between traffic density in the street of residence with oxidative stress and metabolomic profiles measured […]
Integration of metabolome and microbiome omics layers toward pancreatic cancer risk prediction
Abstract Background: Pancreatic cancer (PC) is projected to become the second most mortal type of cancer by 2030. Several factors increase the PC risk. However, these conditions are not enough to define high-risk populations towards preventive interventions. Oral and gut microbiota have been associated with PC risk, and a gut microbiota signature has shown to […]
Advanced Lipoproteins and Lipidomic Profile in Bariatric Surgery
Abstract Background: Obesity is related to cardiovascular risk factors (CVRF) such as dyslipidemia, diabetes, and hypertension, which increase mortality. Basic lipid determinations could underestimate the true atherogenic risk of patients and the impact of bariatric surgery. The objective of the study is to demonstrate the change in the advanced molecular profile of lipoproteins determined by nuclear […]
Asociación entre contaminación del aire y lípidos en sangre en España
Resumen Antecedentes y objetivos: Nuestro objetivo fue evaluar las asociaciones entre la exposición a contaminantes atmosféricos y medidas estándar y avanzadas de lipoproteínas, en una muestra a nivel nacional representativa de la población adulta de España. Métodos: Incluimos a 4647 adultos (>18 años), participantes en el estudio nacional, transversal y poblacional di@bet.es, realizado entre 2008 […]
Fusión de redes de similitud para identificar fenotipos de fetos pequeños para edad gestacional
Resumen La restricción del crecimiento fetal (RCF) afecta al 5-10% de los embarazos, siendo el mayor contribuyente a la muerte fetal, y puede tener consecuencias a largo plazo para el niño. La implementación de un sistema de clasificación clínica estándar se ve obstaculizada por el espectro multifenotípico de fetos pequeños con diferencias sustanciales en los […]
Serum branch-chained amino acids are increased in type 2 diabetes
Abstract Background and aim: Circulating biomarkers of metabolic and cardiovascular diseases can help in the early detection and prevention of those diseases. Using proton nuclear magnetic resonance (1H-NMR), we aimed to study the plasma levels of low-molecular-weight metabolites (LMWMs) in a cohort of 307 patients with metabolic diseases to assess their relationships with type-2 diabetes (T2D) […]
Increase in Inflammation-Linked Glycoproteins and a Proatherogenic Lipoprotein Profile in Psychosis
Abstract Minimally invasive prognostic markers of inflammation and dyslipidemia in individuals with a risk of psychosis, also called «at-risk mental state» (ARMS), or in the first episode of psychosis (FEP) are of utmost clinical importance to prevent cardiovascular disorders. We analyzed the plasma concentration of inflammation-linked glycoproteins (Glycs) and lipoprotein subclasses by proton nuclear magnetic […]
NMR-based metabolomic profiling identifies inflammation and muscle-related metabolites as predictors of incident type 2 diabetes mellitus beyond glucose: The Di@bet.es study
Abstract Aims: The aim of this study was to combine nuclear magnetic resonance-based metabolomics and machine learning to find a glucose-independent molecular signature associated with future type 2 diabetes mellitus development in a subgroup of individuals from the Di@bet.es study. Methods: The study group included 145 individuals developing type 2 diabetes mellitus during the 8-year follow-up, 145 […]
