Early molecular signature of Parkinson and dementia years before the diseases appear

NMR metabolomics could identify altered lipoprotein and protein glycosylation profiles in REM sleep behavior disorder (iRBD), the prodromal stage of Lewy-type synucleinopathies (LTS) -including Parkinson and dementia.

NMR showed predictive power distinguishing future clinical outcome, being a useful tool for identifying short-term high-risk patients for conversion to parkinsonism or dementia.

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